JAMA Current Issue http://www.elizeaboutbeauty.com/journals/jama en-us Tue, 13 Apr 2021 00:00:00 GMT Tue, 13 Apr 2021 11:43:24 GMT Silverchair jamams@jamanetwork.org support@www.elizeaboutbeauty.com Teplizumab Improves Beta Cell Function, Delays Type 1 Diabetes http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778514 Tue, 13 Apr 2021 00:00:00 GMT Abbasi J. The investigational monoclonal antibody teplizumab improved beta cell function among high-risk relatives of individuals with type 1 diabetes in a phase 2 randomized clinical trial, according to extended follow-up data published in Science Translational Medicine. A previously reported delay in diabetes development among treated participants also increased. 325 14 1385 1385 10.1001/jama.2021.4628 2778514 Data Leak Exposes Early COVID-19 Vaccine Manufacturing Hiccups http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778513 Tue, 13 Apr 2021 00:00:00 GMT Abbasi J. After a cyberattack late last year against the European Medicines Agency (EMA), anonymous emails dispatched a trove of classified documents to academics and journalists. 325 14 1385 1385 10.1001/jama.2021.5002 2778513 Wearable Bilirubin Measurement Device for Neonatal Jaundice http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778512 Tue, 13 Apr 2021 00:00:00 GMT Abbasi J. Jaundice, caused by high levels of the reddish-yellow pigment bilirubin in blood, affects more that 80% of newborns. Although neonatal jaundice usually resolves with treatment, severe hyperbilirubinemia can cause a form of brain damage called kernicterus or bilirubin-induced neurologic dysfunction (BIND). In low- and middle-income countries, jaundice is a major cause of neonatal death and brain damage. 325 14 1385 1385 10.1001/jama.2021.5004 2778512 Incorrect Values in Table http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778511 Tue, 13 Apr 2021 00:00:00 GMT In the Original Investigation titled “Effects of Improvisational Music Therapy vs Enhanced Standard Care on Symptom Severity Among Children With Autism Spectrum Disorder: the TIME-A Randomized Clinical Trial,â€?published in the August 8, 2017, issue of JAMA, values were incorrect in Table 1. In the “Valueâ€?column under “Enhanced Standard Care,â€?the No. (%) values for boys should have been reported as 153 (84.1); for native speaker of the country’s main language as 169 (92.9); for previous music therapy as 4 (2.2); and for mental retardation as 84 (44.5). This article was corrected online. 325 14 1473 1473 10.1001/jama.2021.4108 2778511 Crucial Questions for US Health Policy in the Next Decade http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778510 Tue, 13 Apr 2021 00:00:00 GMT Ayanian JZ. With the inauguration of President Biden and a shift in control of the US Senate from Republicans to Democrats, the landscape for health policy has changed substantially in 2021. Just as the signing of the Affordable Care Act (ACA) by President Obama in 2010, along with sustained Republican opposition to this landmark law, set the health policy agenda for the past decade, the actions of the new president and Congress this year will determine how the US health care system functions and changes over the next decade. 325 14 1397 1399 10.1001/jama.2021.1470 2778510 Confronting Challenges in the US Health Care System http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778509 Tue, 13 Apr 2021 00:00:00 GMT Buntin MB. The sheer number of challenges facing the Biden Administration and the 117th Congress in the health policy sphere is staggering, as is the range of potential solutions offered by the authors of the Viewpoints in the JAMA Health Policy series. The most pressing challenges involve addressing the global COVID-19 pandemic. Yet policy makers would be remiss if they did not leverage this opportunity to also address the fundamental problems with the US health system laid bare by the nation’s response to the pandemic. These include major challenges related to health insurance coverage, the solvency of publicly funded programs, the stability of the health care safety net, market power and consolidation, inequities in health care access and outcomes, public health infrastructure, and the failure to effectively use technology to help counteract these problems. 325 14 1399 1400 10.1001/jama.2021.1471 2778509 The Near-Term Future of Health Care Reform http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778508 Tue, 13 Apr 2021 00:00:00 GMT Emanuel EJ. Over the past decade, the US has made progress on the core problems of access, cost, and quality involving health care. Although it is valuable, this progress seems inadequate compared with the magnitude of the challenges. Approximately 20 million individuals in the US have received insurance coverage because of the Affordable Care Act (ACA), yet an estimated 29 million (approximately 9% of the US population) remain uninsured. In addition, over the past decade, health care costs have stabilized at approximately 18% of gross domestic product, yet per capita costs are far higher than all other high-income countries, including Switzerland and Norway, in part because of an estimated nearly $1 trillion in annual waste. A similar pattern holds for quality: improvement, but persistent underperformance relative to spending. For example, only 43.7% of adults in the US with hypertension had their blood pressure appropriately assessed and managed in 2017-2018. 325 14 1394 1397 10.1001/jama.2021.1472 2778508 USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778507 Tue, 13 Apr 2021 00:00:00 GMT Burnett-Bowie SM, Cappola AR. Interest in the relationship between vitamin D and health has increased over the past decade, with concurrent increases in the number of 25-hydroxyvitamin D (25[OH]D) assays performed and in the use of vitamin D supplements. In 2011, the National Academy of Medicine determined that a 25(OH)D level less than 20 ng/mL (49.9 nmol/L) was consistent with deficiency and that there was no evidence for different 25(OH)D thresholds for different health conditions. This recommendation resulted in vigorous debate within the medical and scientific community regarding the merits of screening for vitamin D deficiency and the goal 25(OH)D levels in healthy persons as well as those with certain chronic conditions. In the 2014 National Health and Nutrition Examination Survey (NHANES), an estimated 25% of the US population was vitamin D deficient, with 5% of individuals 1 year or older with 25(OH)D levels less than 12 ng/mL and 18% with 25(OH)D levels between 12 and 19 ng/mL. 325 14 1401 1402 10.1001/jama.2021.2227 2778507 Audio Highlights http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778506 Tue, 13 Apr 2021 00:00:00 GMT Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA. 325 14 e2017881 10.1001/jama.2020.17881 2778506 Time to Rethink Nursing Homes http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778504 Tue, 13 Apr 2021 00:00:00 GMT Butler SM. Hundreds of thousands of people who are older and disabled live in nursing homes not because they need specialized care or want to live in those facilities, but because Medicaid payment rules make that the only housing with daily living care they can afford. 325 14 1383 1384 10.1001/jama.2021.2567 2778504 Neurology in Art http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778503 Tue, 13 Apr 2021 00:00:00 GMT In 1861, the medical historian K. F. X. Marx published an essay of seventy-four pages on medicine in the graphic arts, containing the first list of paintings and engravings relating to medicine. Unnoticed in its time, this pamphlet opened a new pathway of research which has since been retraced and extended by many investigators, more particularly in the subsequent lists made by Sudhoff, in the well known illustrated books of Charcot, Holländer, Müllerheim and Parkes-Weber, and in various magazine articles of more recent date. The subject is one of immense interest to the physician who loves his profession, for paintings and engravings, old and new, tell more about the physician’s social and professional status in the different periods than does the printed literature. Many diseases have been accurately represented (without diagnosis tag) in the paintings and sculptures of the past. 325 14 1475 1475 10.1001/jama.2020.17882 2778503 Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778500 Tue, 13 Apr 2021 00:00:00 GMT Ehrenreich H, Neubauer A, Miskowiak K. To the Editor The Research Letter by Dr Natalucci and colleagues reported no benefits of early high-dose recombinant human erythropoietin (rhEpo) on neurodevelopmental outcomes at age 5 years in very preterm infants. We are concerned about the interpretation of this study because the enrolled neonates carried a very low risk of brain damage, given their average birth weight of 1200 g and average gestational age of more than 29 weeks. In 2016, the same authors and, recently, others reported no advantage of rhEpo in preterm infants when examining neurodevelopmental outcome at age 2 years. We previously voiced criticism about the unfounded selection of the 2-year time point, and we are concerned these publications will hamper beneficial use of rhEpo treatment in preterm infants. 325 14 1470 1471 10.1001/jama.2021.0833 2778500 Review of Gastroesophageal Reflux Disease http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778499 Tue, 13 Apr 2021 00:00:00 GMT Mehta RS, Staller K, Chan AT. To the Editor In their Review about gastroesophageal reflux disease (GERD), Dr Maret-Ouda and colleagues discussed risk factors and treatment options for GERD, including surgery and advanced endoscopic techniques. However, we believe they overlooked several recommendations that may benefit patients with heartburn. 325 14 1472 1472 10.1001/jama.2021.1438 2778499 Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years—Reply http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778498 Tue, 13 Apr 2021 00:00:00 GMT Natalucci G, Bucher H, Fauch؈re J. In Reply Before exposing preterm infants to erythropoietin for neuroprotection, potential benefits and safety need to be assessed using the highest possible level of evidence by performing randomized clinical trials instead of extrapolating results from retrospective analyses in neonates exposed to diverse doses of erythropoietin for the prevention of anemia of prematurity. Our recent study demonstrated no significant difference in neurodevelopmental outcomes at age 5 years in children born at 26 to 32 weeksâ€?gestation treated with early high-dose rhEpo compared with saline during the first 2 days of life. These findings confirm those of the primary outcome analysis at age 2 years and do not support the prophylactic administration of short-term, high-dose rhEpo immediately after birth for neuroprotection in the population studied. The outcome data complemented that of the Preterm Erythropoietin Neuroprotection Trial (PENUT), in which infants born between 24 and 28 weeksâ€?gestation were exposed to rhEpo at lower doses and over a much longer period. Despite methodological differences, both trials showed that rhEpo administered immediately after birth was not associated with adverse effects in very preterm neonates. 325 14 1471 1472 10.1001/jama.2021.0836 2778498 Review of Gastroesophageal Reflux Disease—Reply http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778497 Tue, 13 Apr 2021 00:00:00 GMT Maret-Ouda J, Markar SR, Lagergren J. In Reply We agree with Dr Mehta and colleagues that lifestyle interventions may reduce heartburn symptoms among patients with GERD. As highlighted in our Review, there is solid evidence to advise patients with GERD to lose weight if they are obese and to abstain from smoking. However, currently available data regarding lifestyle changes are limited, and studies have often shown divergent results. Associations between dietary or beverage modifications and GERD symptoms are weak, and large population-based studies have often failed to provide reproducible results. Although the currently available medical literature is not sufficiently strong to provide general clinical recommendations, current knowledge can be used for a more individualized approach regarding lifestyle recommendations, including avoidance of dietary factors that provoke symptoms of GERD. 325 14 1472 1473 10.1001/jama.2021.1444 2778497 Patient Information: Screening for Vitamin D Deficiency in Adults http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778492 Tue, 13 Apr 2021 00:00:00 GMT Jin J. This JAMA Patient Page summarizes the US Preventive Services Task Force’s 2021 recommendation that current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults (I statement). 325 14 1480 1480 10.1001/jama.2021.4606 2778492 Winter of Fear http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778491 Tue, 13 Apr 2021 00:00:00 GMT Coffelt A. For Aviya 325 14 1474 1474 10.1001/jama.2021.1609 2778491 On Mentoring—A Meditation of Gratitude http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778490 Tue, 13 Apr 2021 00:00:00 GMT Bauchner H. In this narrative medicine essay, JAMA’s editor in chief remembers his career mentors and their selflessness as they guided him in his early and mid-career and later became friends and colleagues. 325 14 1393 1393 10.1001/jama.2021.4070 2778490 JAMA http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778489 Tue, 13 Apr 2021 00:00:00 GMT 325 14 1369 1370 10.1001/jama.2020.17879 2778489 USPSTF Review: Screening for Vitamin D Deficiency in Adults http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778488 Tue, 13 Apr 2021 00:00:00 GMT Kahwati LC, LeBlanc E, Weber R, et al. This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on screening for vitamin D deficiency summarizes published evidence on the benefits and harms of screening and interventions for vitamin D deficiency in asymptomatic, community-dwelling adults. 325 14 1443 1463 10.1001/jama.2020.26498 2778488 USPSTF Recommendation: Screening for Vitamin D Deficiency in Adults http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778487 Tue, 13 Apr 2021 00:00:00 GMT , Krist AH, Davidson KW, et al. This 2021 US Preventive Services Task Force Recommendation Statement concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults (I statement). 325 14 1436 1442 10.1001/jama.2021.3069 2778487 How the Biden Administration Can Improve Health Equity for Racial and Ethnic Minorities http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778485 Tue, 13 Apr 2021 00:00:00 GMT Joynt Maddox KE, James CV. This Viewpoint outlines actions that the new federal administration could consider related to health care access and quality, and social determinants of health, to meaningfully improve health equity for racial/ethnic minority populations. 325 14 1387 1388 10.1001/jama.2021.3046 2778485 Disparities in Suicide Persist Despite Overall Dip in US Rate http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778483 Tue, 13 Apr 2021 00:00:00 GMT Kuehn BM. After increasing by about one-third for nearly 2 decades, the overall US suicide rate dipped by about 2% between 2018 and 2019. However, CDC researchers reported that the improvements didn’t extend to all racial and ethnic groups. 325 14 1386 1386 10.1001/jama.2021.4131 2778483 COVID-19 Precautions Are Scarce in Non–Health Care Workplaces http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2778482 Tue, 13 Apr 2021 00:00:00 GMT Kuehn BM. Less than half of US workers in non–health care fields had COVID-19 prevention measures in place at work as of June 2020, based on an online survey of 4000 US, nonremote workers. 325 14 1386 1386 10.1001/jama.2021.4844 2778482 How the US Failed to Prioritize SARS-CoV-2 Variant Surveillance http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2777988 Tue, 13 Apr 2021 00:00:00 GMT Abbasi J. This Medical News article discusses genomic sequencing to detect and track virus variants during the COVID-19 pandemic. 325 14 1380 1382 10.1001/jama.2021.3368 2777988 COVID-19 Postage Stamps—Messages in a Message http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2777922 Tue, 13 Apr 2021 00:00:00 GMT Lefr؈re B, Recoing A, Delacour H. This Arts and Medicine feature presents global postage and commemorative stamps issued by countries and nongovernmental organizations in 2020 featuring coronavirus pandemic-related themes. 325 14 1377 1379 10.1001/jama.2021.2139 2777922 Effect of Weekly Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2777886 Tue, 13 Apr 2021 00:00:00 GMT Rubino D, Abrahamsson N, Davies M, et al. This randomized trial compares the effects of continuing weekly treatment with subcutaneous semaglutide vs switching to placebo on change in body weight over 48 weeks among adults with overweight or obesity who completed a 20-week run-in period with semaglutide. 325 14 1414 1425 10.1001/jama.2021.3224 2777886 National Initiatives to Prevent Myocardial Infarction and Stroke http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2777651 Tue, 13 Apr 2021 00:00:00 GMT Frieden TR, Foti KE. This Viewpoint discusses the Million Hearts initiative, a national effort that aims to prevent a million myocardial infarctions and strokes over 5 years, and proposes actions and strategies federal agencies can take to advance tobacco control, sodium reduction, trans fat elimination, hypertension control, and centering the US health care system on primary care. 325 14 1391 1392 10.1001/jama.2021.0905 2777651 COVID-19 in 2021—Continuing Uncertainty http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2777391 Tue, 13 Apr 2021 00:00:00 GMT del Rio C, Malani P. This Viewpoint summarizes the current best evidence about COVID-19 vaccines, immunity, and whether SARS-CoV-2 will become an endemic or seasonal virus. 325 14 1389 1390 10.1001/jama.2021.3760 2777391 Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19 http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2777389 Tue, 13 Apr 2021 00:00:00 GMT LÙQpez-Medina E, LÙQpez P, Hurtado IC, et al. This randomized trial compares the effects of ivermectin vs placebo on time to symptom resolution within 21 days among patients with mild COVID-19. 325 14 1426 1435 10.1001/jama.2021.3071 2777389 Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2 http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2777171 Tue, 13 Apr 2021 00:00:00 GMT Saadat S, Rikhtegaran Tehrani Z, Logue J, et al. This study compares titers of binding and neutralizing antibodies after a single mRNA coronavirus vaccine dose in health care workers previously infected with SARS-CoV-2. 325 14 1467 1469 10.1001/jama.2021.3341 2777171 Effect of Subcutaneous Semaglutide on Body Weight in Adults With Obesity http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2777025 Tue, 13 Apr 2021 00:00:00 GMT Wadden TA, Bailey TS, Billings LK, et al. This randomized clinical trial compares the effects of once-weekly subcutaneous semaglutide vs placebo for weight management as an adjunct to intensive behavioral therapy with initial low-calorie diet in adults with overweight or obesity. 325 14 1403 1413 10.1001/jama.2021.1831 2777025 Identifying COVID-19 Risk Through Observational Studies to Inform Control Measures http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2776937 Tue, 13 Apr 2021 00:00:00 GMT Tenforde MW, Fisher KA, Patel MM. This JAMA Insights Clinical Update from the CDC’s COVID-19 Response Team discusses the importance of observational data for identifying behaviors associated with SARS-CoV-2 transmission, and presents data suggesting that indoor eating or drinking poses the highest risk, presumably because of prolonged exposure to unmasked, non–physically distanced companions. 325 14 1464 1465 10.1001/jama.2021.1995 2776937 SOFA Score Accuracy for Determining Mortality of Severely Ill Patients With COVID-19 Pneumonia http://www.elizeaboutbeauty.com/journals/jama/fullarticle/2776737 Tue, 13 Apr 2021 00:00:00 GMT Raschke RA, Agarwal S, Rangan P, et al. This cohort study characterizes the accuracy of the Sequential Organ Failure Assessment (SOFA) score to discriminate death from survival in patients with COVID-19 pneumonia receiving oxygen therapy for 4 hours or longer before undergoing endotracheal intubation. 325 14 1469 1470 10.1001/jama.2021.1545 2776737 4887王中王鉄算 盘开奖结果小说