JAMA Neurology Current Issue http://www.elizeaboutbeauty.com/journals/jamaneurology en-us Thu, 01 Apr 2021 00:00:00 GMT Thu, 08 Apr 2021 11:43:35 GMT Silverchair jamams@jamanetwork.org support@www.elizeaboutbeauty.com Errors in Figure http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2778011 Thu, 01 Apr 2021 00:00:00 GMT The Brief Report titled “Agent Orange Exposure and Dementia Diagnosis in US Veterans of the Vietnam Era,â€?published online January 25, 2021, had errors in the Figure. The numbers of patients noted in the labels on the 2 lines on the graph should have been reversed, with the upper line labeled “Agent Orange (nâ€?â€?8â€?21)â€?and the lower line labeled “No Agent Orange (nâ€?â€?78â€?30).â€?In addition, on the x-axis, the final value should have been 85, rather than 55, years. These errors have been corrected. 78 4 497 497 10.1001/jamaneurol.2021.0352 2778011 JAMA Neurology http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2777992 Thu, 01 Apr 2021 00:00:00 GMT Mission Statement: The mission of JAMA Neurology is to publish scientific information primarily important for those physicians caring for people with neurologic disorders but also for those interested in the structure and function of the normal and diseased nervous system. These specific aims are (1) to make timely publication of original research of the nervous system, (2) to record observations of single patients or groups of patients that will provide new information and insights, (3) to report more basic research that is pertinent to the understanding of disease, (4) to introduce topics of practice, ethics, teaching, and history that are useful, and (5) to provide a forum for discussion on topics that may be controversial in this field. This information will be published only after extensive peer review so that originality, clarity, and precision are ensured. 78 4 375 375 10.1001/jamaneurol.2020.3655 2777992 Risk of Hemorrhagic Stroke in Patients With Coronavirus Disease 2019—Reply http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2776959 Thu, 01 Apr 2021 00:00:00 GMT Merkler AE, Zhang C, Navi BB. In Reply We thank Dr Silverman and colleagues for their interest in our study and providing us the opportunity to expand on our results. Among the 1916 patients who visited the emergency department or were hospitalized with coronavirus disease 2019 (COVID-19) in our study, 8 patients (0.4% [95% CI, 0.2%-0.8%]) had hemorrhagic stroke, including 7 with intracerebral hemorrhage and 1 with subarachnoid hemorrhage. Among these 8 patients, 4 strokes were attributed to anticoagulant use. 78 4 497 497 10.1001/jamaneurol.2021.0120 2776959 Risk of Hemorrhagic Stroke in Patients With Coronavirus Disease 2019 http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2776958 Thu, 01 Apr 2021 00:00:00 GMT Silverman M, Devlin M, Krawczyk M. To the Editor We read with interest the article by Merkler et al regarding the increased incidence of ischemic stroke in patients with coronavirus disease 2019 (COVID-19) compared with those with influenza. The authors also reported that 13% of patients with COVID-19 were receiving anticoagulation at the time of the stroke. Could the authors comment on the rate of anticoagulant use in patients with COVID-19 who did not have an ischemic stroke? This would also be helpful to assess the possibility that anticoagulation may have been protective. 78 4 496 497 10.1001/jamaneurol.2021.0117 2776958 No Visitors Allowed http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2776795 Thu, 01 Apr 2021 00:00:00 GMT Cuevas E. This essay describes the author’s experience of not being able to visit and advocate for her mother in the intensive care unit during the coronavirus disease 2019 pandemic. 78 4 381 382 10.1001/jamaneurol.2021.0050 2776795 Living to Dream—Reply http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2776792 Thu, 01 Apr 2021 00:00:00 GMT Leary EB, Stone KL, Mignot E. In Reply We thank Bliwise and Trotti for their interest in our findings showing that lower amounts of rapid eye movement (REM) sleep were associated with increased rates of mortality in 2 distinct population-based studies. Since this article was published, we have tested our findings in a third cohort, the Sleep Heart Health Study, and observed consistent outcomes (hazard ratio, 1.13 [95% CI, 1.07-1.18]). The Sleep Heart Health Study includes 5550 participants (47.6% men; 84.6% white) of a mean (SD) age of 63.0 (11.2) years at baseline who were monitored for a median of 11.9 years. A meta-analysis of all 3 cohorts yielded an overall hazard ratio of 1.13 (95% CI, 1.10-1.17; overall effect Pâ€?amp;lt;â€?001) for all-cause mortality in more than 10â€?00 participants, making it an extraordinarily robust finding across a broad age range and diverse racial/ethnic groups. 78 4 495 496 10.1001/jamaneurol.2021.0056 2776792 Living to Dream http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2776791 Thu, 01 Apr 2021 00:00:00 GMT Bliwise DL, Trotti L. To the Editor We read with great enthusiasm the fascinating report by Leary et al that lower rapid eye movement (REM) sleep amounts are associated with reduced survival, a finding sufficiently robust to withstand adjustments for sleep apnea, abnormal sleep duration, imminent death, and depression and independently replicated in another cohort. The accompanying Editorial posed the provocative question of whether this finding might have any practical use to a clinical neurologist. A separate question raised from these data is whether interindividual variability in REM percentage, compared with other sleep features, might provide another clue to REM’s biological importance. As evidenced by coefficients of variation (COV) (SDâ€? mean ×â€?00) for REM percentage within these cohorts, 34.4% for the Outcomes of Sleep Disorders in Older Men (MrOS) Sleep Study and 36.9% for the Wisconsin Sleep Cohort (WSC), differences across individuals in this measure are quite small. By contrast, their magnitude is greatly exceeded by COVs of conditions with known morbidity that neurologists typically treat, such as sleep apnea, for which COVs for the apnea hypopnea index (with a mean calculated across quartiles) were 75.7% and 131.6% for the MrOS and WSC studies, respectively, and for periodic leg movements (often treated when accompanied by restless legs), for which COVs (with a mean calculated across quartiles) were 105.1% and 84.9% for the MrOS and WSC studies, respectively. Apart from disease, perhaps even more striking were the restricted REM COVs in comparison with other prominent sleep architecture features not constituting disease in their own right. For the percentage in N3 (78.4% and 76.6% for the MrOS and WSC studies, respectively), a stage fundamentally constituted by slow waves, the loss of which is often considered to reflect decreased synaptic density and memory consolidation deficits, COVs were twice as large. The current article is not the first report from the MrOS study suggesting that REM, rather than N3, may hold greater significance in this cohort, although the finding’s resilience in the WSC study (with similar REM COVs), greatly enhances the likelihood of generalizability. 78 4 495 495 10.1001/jamaneurol.2021.0053 2776791 Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2776783 Thu, 01 Apr 2021 00:00:00 GMT Meyer L, Stracke C, Jungi N, et al. This case-control study analyzes the clinical, functional, and safety outcomes associated with endovascular therapy for patients with posterior circulation distal, medium vessel occlusion. 78 4 434 444 10.1001/jamaneurol.2021.0001 2776783 Error in Author Name and Change to Open Access http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2776782 Thu, 01 Apr 2021 00:00:00 GMT In the Original Investigation titled “Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease: A Randomized Clinical Trial,â€?published online December 14, 2020, the 14th author’s first name was misspelled. Dr Adams’s name should be spelled “Jamie Adams.â€?The status of this article has also been changed to open access under a CC-BY license. This article was corrected online. 78 4 497 497 10.1001/jamaneurol.2021.0103 2776782 Long-term Socioeconomic Outcomes Associated With Pediatric-Onset Multiple Sclerosis http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2776781 Thu, 01 Apr 2021 00:00:00 GMT McKay KA, Friberg E, Razaz N, et al. This cohort study evaluates the association between pediatric-onset multiple sclerosis and education and income throughout adulthood. 78 4 478 482 10.1001/jamaneurol.2020.5520 2776781 To Screen or Not to Screen for Carotid Stenosis http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2776047 Thu, 01 Apr 2021 00:00:00 GMT Chaturvedi S. This editorial discusses the screening for carotid stenosis recommendation statement by the US Preventive Services Task Force. 78 4 383 384 10.1001/jamaneurol.2020.5382 2776047 Aggregated Tau and the Associated Risk of Clinical Progression http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2775982 Thu, 01 Apr 2021 00:00:00 GMT Lu M, Pontecorvo MJ, Devous MD, Sr, et al. This study evaluates the association between flortaucipir positron emission tomography visual interpretation and patientsâ€?near-term clinical progression of mild cognitive impairment and dementia owing to Alzheimer disease. 78 4 445 453 10.1001/jamaneurol.2020.5505 2775982 Cortical Vein Thrombosis, Tortuous Venous Vasculature, and Microhemorrhages in Neurosarcoidosis http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2775981 Thu, 01 Apr 2021 00:00:00 GMT Kammeyer R, Schreiner T. This case report describes a 13-year-old boy who presented with an episode of left-sided facial droop and dysarthria lasting 90 minutes. 78 4 491 492 10.1001/jamaneurol.2020.5440 2775981 Comparison of Corticosteroid Tapering Regimens in Myasthenia Gravis http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2775980 Thu, 01 Apr 2021 00:00:00 GMT Sharshar T, Porcher R, Demeret S, et al. This parallel-group, randomized, single-blind clinical trial compares rapid- with slow-tapering dosing regimens of prednisone in patients with generalized myasthenia gravis who have achieved minimal manifestation status. 78 4 426 433 10.1001/jamaneurol.2020.5407 2775980 Seizure Cycles in Focal Epilepsy http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2775979 Thu, 01 Apr 2021 00:00:00 GMT Leguia MG, Andrzejak RG, Rummel C, et al. This cohort study uses data from continous intracranial electroencephalography and seizure diaries to investigate the prevalence, strength, and temporal patterns of seizure cycles over timescales of hours to years. 78 4 454 463 10.1001/jamaneurol.2020.5370 2775979 Identification of Candidate Parkinson Disease Genes Using Genome-Wide Association Study, Expression, and Epigenetic Data Sets http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2775977 Thu, 01 Apr 2021 00:00:00 GMT Kia DA, Zhang D, Guelfi S, et al. This genetic association study investigates what genes and genomic processes underlie the risk of sporadic Parkinson disease. 78 4 464 472 10.1001/jamaneurol.2020.5257 2775977 Association of Glycolysis-Enhancing ‚Î-1 Blockers With Risk of Developing Parkinson Disease http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2775976 Thu, 01 Apr 2021 00:00:00 GMT Simmering JE, Welsh MJ, Liu L, et al. This cohort study investigates whether use of terazosin, doxazosin, and alfuzosin is associated with a decreased risk of developing Parkinson disease compared with use of tamsulosin. 78 4 407 413 10.1001/jamaneurol.2020.5157 2775976 Error in Figure and Table http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2774862 Thu, 01 Apr 2021 00:00:00 GMT In the Original Investigation titled “Effect of Motor Skill Training in Functional Activities vs Strength and Flexibility Exercise on Function in People With Chronic Low Back Pain: A Randomized Clinical Trial,â€?published online December 28, 2020, there were errors in Figure 1 and Table 3. In the “Excludedâ€?box of Figure 1, rows 6, 7, and 9 to 14 should all be indented. Additionally, row 5 should read â€?6 During first visitâ€?and row 8 should read â€?40 Had no first visit scheduled.â€?In Table 3, row 40, column 3 should read â€?0 (21)â€?and row 40, column 4 should read â€?1 (35).â€?This article has been corrected online. 78 4 497 497 10.1001/jamaneurol.2020.5321 2774862 Agent Orange Exposure and Dementia Diagnosis in US Veterans of the Vietnam Era http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2774857 Thu, 01 Apr 2021 00:00:00 GMT Martinez S, Yaffe K, Li Y, et al. This study examines the association between Agent Orange exposure and incident dementia diagnosis among US veterans who served in the Vietnam era. 78 4 473 477 10.1001/jamaneurol.2020.5011 2774857 Effect of Motor Skill Training vs Strength and Flexibility Exercise on Function in Chronic Low Back Pain http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2774481 Thu, 01 Apr 2021 00:00:00 GMT van Dillen LR, Lanier VM, Steger-May K, et al. This randomized clinical trial investigates whether an exercise-based treatment of person-specific motor skill training (MST) in performance of functional activities is more effective in improving function than strength and flexibility exercise immediately, 6 months, and 12 months following treatment. 78 4 385 395 10.1001/jamaneurol.2020.4821 2774481 Bilateral Vagus Nerve Enhancement in a Patient With Leptomeningeal Lymphoplasmacytic Lymphoma Presenting with Intractable Hiccups http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2774480 Thu, 01 Apr 2021 00:00:00 GMT Mustafa R, Neth BJ, Stitt D. This case report describes a 73-year-old man who presented with intractable hiccups and lymphoplasmacytic lymphoma. 78 4 493 494 10.1001/jamaneurol.2020.4830 2774480 Adolescent-Onset and Adult-Onset Vitamin-Responsive Neurogenetic Diseases http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2774468 Thu, 01 Apr 2021 00:00:00 GMT Mandia D, Shor N, Benoist J, et al. This narrative review describes adolescent-onset and adult-onset vitamin-responsive neurogenetic diseases, their underlying biology, and their treatments. 78 4 483 490 10.1001/jamaneurol.2020.4911 2774468 Blood Phosphorylated Tau181, Neurofilament Light Chain, and Neurodegeneration in Alzheimer Disease http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2774467 Thu, 01 Apr 2021 00:00:00 GMT Moscoso A, Grothe MJ, Ashton NJ, et al. This cohort study uses data from the Alzheimer’s Disease Neuroimaging Initiative study to investigate if blood-based biomarkers can be used to monitor the progression of Alzheimer disease neurodegeneration. 78 4 396 406 10.1001/jamaneurol.2020.4986 2774467 Perils of Race-Based Norms in Cognitive Testing http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2774316 Thu, 01 Apr 2021 00:00:00 GMT Possin KL, Tsoy E, Windon CC. This Viewpoint explains the practice and perils of using race-adjusted norms and proposes a new approach that could replace the current standard in the National Football League. 78 4 377 378 10.1001/jamaneurol.2020.4763 2774316 The Future Is P-Tau—Anticipating Direct-to-Consumer Alzheimer Disease Blood Tests http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2774173 Thu, 01 Apr 2021 00:00:00 GMT Largent EA, Wexler A, Karlawish J. This Viewpoint describes the benefits and challenges offered by emerging direct-to-consumer tests for Alzheimer disease through measurement of blood levels of phosphorylated tau. 78 4 379 380 10.1001/jamaneurol.2020.4835 2774173 Identifying the Distinct Cognitive Phenotypes in Multiple Sclerosis http://www.elizeaboutbeauty.com/journals/jamaneurology/fullarticle/2774172 Thu, 01 Apr 2021 00:00:00 GMT De Meo E, Portaccio E, Giorgio A, et al. This cross-sectional study presents a data-driven classification of cognitive functions in patients with multiple sclerosis. 78 4 414 425 10.1001/jamaneurol.2020.4920 2774172 4887王中王鉄算 盘开奖结果小说