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          Special Communication
          November?18, 2020

          Leveraging Basic Science for the Clinic—From Bench to Bedside

          Author Affiliations
          • 1Clinical Neuroscience Research Unit, Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut
          • 2National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland
          JAMA Psychiatry. Published online November 18, 2020. doi:10.1001/jamapsychiatry.2020.3656

          Importance? The tools and insights of behavioral neuroscience grow apace, yet their clinical application is lagging.

          Observations? This article suggests that associative learning theory may be the algorithmic bridge to connect a burgeoning understanding of the brain with the challenges to the mind with which all clinicians and researchers are concerned.

          Conclusions and Relevance? Instead of giving up, talking past one another, or resting on the laurels of face validity, a consilient and collaborative approach is suggested: visiting laboratory meetings and clinical rounds and attempting to converse in the language of behavior and cognition to better understand and ultimately treat patients.

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            1 Comment for this article
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            Where are the biomarkers?
            David Lewis |
            This article makes it sound like the lack of clinical applications of purported revolutionary insights of neuroscience into psychopathology is a failure of communication, ingenuity or will.

            But if so, why are there no clinically actionable biomarkers for psychiatric disorders -- none, zero -- based on any neuro-technology, biochemical or image-based!

            Sorry, but if brain science can't even reliably diagnose an individual's depression or predict the course of a schizophrenia patient's symptoms under various treatments, then the science just isn't there for any clinical application, diagnostic, prognostic or therapeutic. Worse, to hope or predict that such
            success might arrive with "tools on the horizon" is not science but pseudo-scientific wishful thinking, especially given the failure so far.
            CONFLICT OF INTEREST: None Reported
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