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          Year

          Day

          November 19, 2020
          Original Investigation

          Efficacy and Safety of Pembrolizumab in Combination With Bevacizumab and Oral Metronomic Cyclophosphamide in the Treatment of Recurrent Ovarian Cancer: A Phase 2 Nonrandomized Clinical Trial

          Abstract Full Text
          JAMA Oncol. Published online November 19, 2020. doi:10.1001/jamaoncol.2020.5945

          This single-arm, phase 2 nonrandomized clinical trial assesses the efficacy and safety of combined pembrolizumab, bevacizumab, and oral metronomic cyclophosphamide in women with recurrent platinum-sensitive, platinum-resistant, or refractory epithelial ovarian, fallopian tube, or primary peritoneal cancer.

          Reproductive Outcomes After Breast Cancer in Women With vs Without Fertility Preservation

          Abstract Full Text
          open access
          JAMA Oncol. Published online November 19, 2020. doi:10.1001/jamaoncol.2020.5957

          This cohort study investigates the long-term reproductive outcomes in women who did or did not undergo fertility preservation at the time of breast cancer diagnosis.

          Research Letter

          Assessment of Discordance Among Smoldering Multiple Myeloma Risk Models

          Abstract Full Text
          JAMA Oncol. Published online November 19, 2020. doi:10.1001/jamaoncol.2020.5585

          This cohort study assesses the concordance of 3 models to stratify risk for progression to multiple myeloma in an independent cohort of patients with smoldering multiple myeloma.

          Review

          Nonpharmacological Interventions for Managing Breathlessness in Patients With Advanced Cancer: A Systematic Review

          Abstract Full Text
          JAMA Oncol. Published online November 19, 2020. doi:10.1001/jamaoncol.2020.5184

          This systematic review reports the outcomes and evidence in randomized clinical trials of nonpharmacological treatment options for alleviating breathlessness and their implications for clinical guidelines and practice in advanced cancer.

          Viewpoint

          Financial Toxicity From Generic Specialty Drug Use

          Abstract Full Text
          JAMA Oncol. Published online November 19, 2020. doi:10.1001/jamaoncol.2020.5181

          This Viewpoint argues that specialty generics can cost more for patients than brand-name drugs, and proposes strategies to protect patients by addressing the market dysfunction caused by rebates.

          Comment & Response

          Clarification of Definitions of Hyperprogressive Disease During Immunotherapy

          Abstract Full Text
          JAMA Oncol. Published online November 19, 2020. doi:10.1001/jamaoncol.2020.5582

          Clarification of Definitions of Hyperprogressive Disease During Immunotherapy—Reply

          Abstract Full Text
          JAMA Oncol. Published online November 19, 2020. doi:10.1001/jamaoncol.2020.5591
          Correction

          Error in Author Byline Order

          Abstract Full Text
          free access
          JAMA Oncol. Published online November 19, 2020. doi:10.1001/jamaoncol.2020.6492
          November 12, 2020
          Original Investigation

          Assessment of Outcomes After Stopping Tyrosine Kinase Inhibitors Among Patients With Chronic Myeloid Leukemia: A Nonrandomized Clinical Trial

          Abstract Full Text
          has audio
          JAMA Oncol. Published online November 12, 2020. doi:10.1001/jamaoncol.2020.5774

          This nonrandomized clinical trial evaluates molecular recurrence and patient-reported outcomes after tyrosine kinase inhibitor discontinuation in US patients with chronic myeloid leukemia.

          Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: A Nonrandomized Controlled Trial

          Abstract Full Text
          JAMA Oncol. Published online November 12, 2020. doi:10.1001/jamaoncol.2020.5865

          This nonrandomized controlled trial reports the oncological outcomes of the deintensification (from 50 Gy to 36 Gy) of a preoperative radiotherapy regimen for adults with myxoid liposarcoma.

          Brief Report

          Clinical Characteristics, Experiences, and Outcomes of Transgender Patients With Cancer:

          Abstract Full Text
          JAMA Oncol. Published online November 12, 2020. doi:10.1001/jamaoncol.2020.5671

          This case series examines clinical characteristics, experiences, and outcomes of transgender patients with cancer.

          Research Letter

          Association of the COVID-19 Outbreak With Patient Willingness to Enroll in Cancer Clinical Trials

          Abstract Full Text
          open access has active quiz
          JAMA Oncol. Published online November 12, 2020. doi:10.1001/jamaoncol.2020.5748

          This survey study examines the attitudes of a large group of cancer survivors toward trial participation during the coronavirus disease 2019 outbreak.

          JAMA Oncology Clinical Challenge

          Scalp Eruption in a Patient With Metastatic Colon Cancer

          Abstract Full Text
          has active quiz
          JAMA Oncol. Published online November 12, 2020. doi:10.1001/jamaoncol.2020.5176

          A 73-year-old man with metastatic colorectal cancer presents with crusted lesions and purulent drainage on the scalp, with associated pruritus and pain. What is your diagnosis?

          Invited Commentary

          Tyrosine Kinase Inhibitor Discontinuation in Patients With Chronic Myeloid Leukemia: Updates From the LAST Study on Patient-Reported Outcomes and Biomarkers for Relapse

          Abstract Full Text
          JAMA Oncol. Published online November 12, 2020. doi:10.1001/jamaoncol.2020.5772
          Cancer Care Chronicles

          Hope Shattered, Hope Restored

          Abstract Full Text
          JAMA Oncol. Published online November 12, 2020. doi:10.1001/jamaoncol.2020.5191

          This essay describes how an act of kindness can restore one’s hope.

          Comment & Response

          Deferring a Change in the Standard of Care for Small Cell Lung Cancer Brain Metastases

          Abstract Full Text
          JAMA Oncol. Published online November 12, 2020. doi:10.1001/jamaoncol.2020.5466

          Deferring a Change in the Standard of Care for Small Cell Lung Cancer Brain Metastases—Reply

          Abstract Full Text
          JAMA Oncol. Published online November 12, 2020. doi:10.1001/jamaoncol.2020.5473
          November 5, 2020
          Original Investigation

          Efficacy of Circulating Tumor Cell Count–Driven vs Clinician-Driven First-line Therapy Choice in Hormone Receptor–Positive, ERBB2-Negative Metastatic Breast Cancer: The STIC CTC Randomized Clinical Trial

          Abstract Full Text
          JAMA Oncol. Published online November 5, 2020. doi:10.1001/jamaoncol.2020.5660

          This phase 3 randomized clinical trial assesses the efficacy of a clinician-driven treatment choice vs a circulating tumor cell count–driven choice for first-line treatment among women with hormone receptor–positive, ERBB2-negative metastatic breast cancer.

          Effect of Taxane Chemotherapy With or Without Indoximod in Metastatic Breast Cancer: A Randomized Clinical Trial

          Abstract Full Text
          JAMA Oncol. Published online November 5, 2020. doi:10.1001/jamaoncol.2020.5572

          This randomized clinical trial evaluates clinical outcomes in patients with ERBB2-negative metastatic breast cancer treated with indoximod plus a taxane.

          Brief Report

          Association of Clonal Hematopoiesis in DNA Repair Genes With Prostate Cancer Plasma Cell-free DNA Testing Interference

          Abstract Full Text
          open access
          JAMA Oncol. Published online November 5, 2020. doi:10.1001/jamaoncol.2020.5161

          This case series study examines the prevalence of clonal hematopoiesis and its potential interference in prostate cancer cell-free DNA testing.

          Research Letter

          Serial Screening for COVID-19 in Asymptomatic Patients Receiving Anticancer Therapy in the United Arab Emirates

          Abstract Full Text
          open access has active quiz
          JAMA Oncol. Published online November 5, 2020. doi:10.1001/jamaoncol.2020.5745

          This cohort study examines the implementation of a microbiologic screening pilot program in Al Zahra Hospital in the United Arab Emirates for identifying presymptomatic COVID-19 in patients with cancer.

          Viewpoint

          Drug Approvals in Hepatocellular Carcinoma—Filling the Nonexistent Gap?

          Abstract Full Text
          JAMA Oncol. Published online November 5, 2020. doi:10.1001/jamaoncol.2020.4811

          This Viewpoint discusses approvals by the US Food and Drug Administration for first- and second-line chemotherapy drugs—plus the combined use of some agents—used to treat hepatocellular carcinoma.

          Editorial

          Evaluating the Clinical Utility of Circulating Tumor Cells in Metastatic Breast Cancer—Is Not Worse Good Enough?

          Abstract Full Text
          JAMA Oncol. Published online November 5, 2020. doi:10.1001/jamaoncol.2020.5460
          Invited Commentary

          A CHIP in the Armor of Cell-Free DNA–Based Predictive Biomarkers for Prostate Cancer

          Abstract Full Text
          JAMA Oncol. Published online November 5, 2020. doi:10.1001/jamaoncol.2020.5140
          Comment & Response

          Allogeneic Transplant Conditioning Regimens for Patients With Non-Hodgkin Lymphoma

          Abstract Full Text
          JAMA Oncol. Published online November 5, 2020. doi:10.1001/jamaoncol.2020.5158

          Allogeneic Transplant Conditioning Regimens for Patients With Non-Hodgkin Lymphoma—Reply

          Abstract Full Text
          JAMA Oncol. Published online November 5, 2020. doi:10.1001/jamaoncol.2020.5167
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