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          Year

          Day

          November 20, 2020
          Viewpoint

          Older Adults and the Mental Health Effects of COVID-19

          Abstract Full Text
          free access has audio
          JAMA. Published online November 20, 2020. doi:10.1001/jama.2020.21753

          This Viewpoint summarizes evidence suggesting that, counter to expectation, older adults as a group may be more resilient to the anxiety, depression, and stress-related mental health disorders characteristic of younger populations during the COVID-19 pandemic.

          JAMA Clinical Challenge

          A Patient With Dizziness, Chest Pain, Rash, and Nail Changes

          Abstract Full Text
          has active quiz
          JAMA. Published online November 20, 2020. doi:10.1001/jama.2020.15176

          A 40-year-old woman with dizziness and imbalance, a petechial rash on her palms and soles, and a right thumbnail splinter hemorrhage had acute right cerebellar infarcts with a left atrial mass on CT angiogram. What is the diagnosis and what would you do next?

          November 19, 2020
          Viewpoint

          Improving Care for Heart Failure With Reduced Ejection Fraction—A Potential Polypill-Based Strategy

          Abstract Full Text
          free access
          JAMA. Published online November 19, 2020. doi:10.1001/jama.2020.21395

          This Viewpoint proposes that a polypill combination of a β-blocker, renin angiotensin inhibitor, mineralocorticoid receptor antagonist, and sodium-glucose cotransporter 2 inhibitor might be the most efficient way to deliver guideline-directed HFrEF therapy, and proposes a research roadmap to design and evaluate the pill and implementation strategies for getting it to patients.

          How to Leverage the Medicare Program for a COVID-19 Vaccination Campaign

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 19, 2020. doi:10.1001/jama.2020.22720

          This Viewpoint proposes that Medicare claims data could inform the rollout of a COVID-19 vaccination program in the US, including notifying beneficiaries of their risk and prioritization and supporting efforts to allocate the vaccine and monitor its uptake, immunogenicity, and safety.

          November 18, 2020
          Viewpoint

          A Proposed Framework and Timeline of the Spectrum of Disease Due to SARS-CoV-2 Infection: Illness Beyond Acute Infection and Public Health Implications

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 18, 2020. doi:10.1001/jama.2020.22717

          This Viewpoint uses clinical observations of the natural course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to propose 3 phases of illness: acute infection (what people commonly refer to with the COVID-19 designation); postacute hyperinflammatory illness (referred to clinically as multisystem inflammatory syndrome); and late inflammatory sequelae, manifest as enduring cardiac, neurological, and psychological symptoms.

          Editorial

          JAMA Health Forum—A New JAMA Network Specialty Journal

          Abstract Full Text
          free access
          JAMA. Published online November 18, 2020. doi:10.1001/jama.2020.23376
          Medical News & Perspectives

          Looking to Long-term Survivors for Improved Pancreatic Cancer Treatment

          Abstract Full Text
          free access
          JAMA. Published online November 18, 2020. doi:10.1001/jama.2020.21717

          This Medical News article examines how studying the characteristics of long-term pancreatic cancer survivors might improve treatment and boost survival for others who have the disease

          November 16, 2020
          Viewpoint

          COVID-19, Decarceration, and the Role of Clinicians, Health Systems, and Payers: A Report From the National Academy of Sciences, Engineering, and Medicine

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 16, 2020. doi:10.1001/jama.2020.22109

          This Viewpoint summarizes a National Academy of Sciences, Engineering, and Medicine (NASEM) consensus panel report recommending ways to reduce populations in prisons and jails as a means to mitigate SARS-CoV-2 transmission and the roles clinicians, health systems, and insurers can play in in process.

          November 15, 2020
          Original Investigation

          Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial

          Abstract Full Text
          free access has audio
          JAMA. Published online November 15, 2020. doi:10.1001/jama.2020.22258

          This randomized trial examines the effects on cardiovascular outcomes of a carboxylic acid formulation of EPA and DHA (omega-3 CA) with documented favorable effects on lipid and inflammatory markers in patients with atherogenic dyslipidemia and high cardiovascular risk.

          Editorial

          Effects of Omega-3 Fatty Acids on Major Adverse Cardiovascular Events: What Matters Most: the Drug, the Dose, or the Placebo?

          Abstract Full Text
          free access
          JAMA. Published online November 15, 2020. doi:10.1001/jama.2020.22387
          Editor's Note

          Do Omega-3 Fatty Acids Benefit Health?

          Abstract Full Text
          free access
          JAMA. Published online November 15, 2020. doi:10.1001/jama.2020.22898
          November 13, 2020
          Original Investigation

          Association Between Adherence to Fractional Flow Reserve Treatment Thresholds and Major Adverse Cardiac Events in Patients With Coronary Artery Disease

          Abstract Full Text
          JAMA. Published online November 13, 2020. doi:10.1001/jama.2020.22708

          This cohort study assesses adherence to evidence-based fractional flow reserve (FFR) thresholds for percutaneous coronary intervention in Canada between 2013 and 2018, and associations of percutaneous coronary intervention with major adverse clinical outcomes for patients with FFR measures above and beneath ischemic thresholds.

          Viewpoint

          Hospital-Acquired SARS-CoV-2 Infection: Lessons for Public Health

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 13, 2020. doi:10.1001/jama.2020.21399

          This Viewpoint reviews the rare incidence of nosocomial SARS-CoV-2 infection and discusses ways it can be minimized, including use of surgical masks, proper ventilation, physical distancing, eye protection, regular testing, and the availability of sick leave for health care workers.

          The Need for More and Better Testing for COVID-19

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 13, 2020. doi:10.1001/jama.2020.21694

          This Viewpoint proposes criteria for more effective COVID-19 testing strategies to manage population transmission, including use of rapid antigen tests and self-administered nasal and salivary tests, emphasizing that more effective testing alone cannot control the pandemic without continued public health interventions, such as mask wearing, physical distancing, and avoidance of large gatherings.

          Editorial

          Physiology-Based Revascularization Decisions and Improved Clinical Outcomes Following Percutaneous Coronary Interventions

          Abstract Full Text
          JAMA. Published online November 13, 2020. doi:10.1001/jama.2020.22998
          November 12, 2020
          Preliminary Communication

          Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 12, 2020. doi:10.1001/jama.2020.22760

          This randomized trial compares the effects of fluvoxamine, a selective serotonin reuptake inhibitor with immunomodulatory effects vs placebo on a composite of dyspnea or pneumonia and oxygen desaturation among adult outpatients with polymerase chain reaction–confirmed mild coronavirus disease 2019 (COVID-19) illness.

          Editor's Note

          COVID-19 Infection—Preventing Clinical Deterioration

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 12, 2020. doi:10.1001/jama.2020.21720
          November 11, 2020
          Viewpoint

          The Challenges Ahead With Monoclonal Antibodies: From Authorization to Access

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 11, 2020. doi:10.1001/jama.2020.21872

          This Viewpoint discusses questions about clinical indication, supply, distribution, and cost and coverage that will need to be resolved if monoclonal antibodies are be granted Emergency Use Authorization or licensure and become available as treatment for COVID-19.

          Therapy for Early COVID-19: A Critical Need

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 11, 2020. doi:10.1001/jama.2020.22813

          In this Viewpoint, Fauci and NIAID colleagues review leading candidates for treatment of mild to moderate coronavirus disease 2019 (COVID-19) to prevent disease progression and longer-term complications, including emerging antiviral drugs, immune-modulating agents, and antibody-based therapies, and the challenges of developing randomized trials to rapidly evaluate the safety and efficacy of each.

          A Piece of My Mind

          Reflections of a COVID-19 Long Hauler

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 11, 2020. doi:10.1001/jama.2020.22130

          In this narrative medicine essay, an emergency medical physician describes the lasting physical symptoms of a mild case of COVID-19, the effects of the illness on his family and professional community, and the lessons he’s learned about caring for symptomatic patients with normal test results.

          Medical News & Perspectives

          Younger Adults Caught in COVID-19 Crosshairs as Demographics Shift

          Abstract Full Text
          free access has active quiz has audio
          JAMA. Published online November 11, 2020. doi:10.1001/jama.2020.21913

          This Medical News article discusses the health implications of severe acute respiratory syndrome coronavirus 2 infection among young and middle-aged adults.

          November 9, 2020
          Original Investigation

          Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial

          Abstract Full Text
          free access has active quiz has audio
          JAMA. Published online November 9, 2020. doi:10.1001/jama.2020.22240

          This randomized trial compares the effects of hydroxychloroquine vs placebo on clinical status at 14 days (home, requiring noninvasive or invasive ventilation or extracorporeal membrane oxygenation, hospitalized, died) among adults hospitalized with coronavirus disease 2019 (COVID-19).

          Editorial

          Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 9, 2020. doi:10.1001/jama.2020.22389
          November 6, 2020
          JAMA Clinical Guidelines Synopsis

          Recommendations for Follow-up Colonoscopy After Polypectomy

          Abstract Full Text
          has audio
          JAMA. Published online November 6, 2020. doi:10.1001/jama.2020.15001

          This JAMA Clinical Guidelines Synopsis summarizes the US Multi-Society Task Force on Colorectal Cancer’s 2020 recommendations for follow-up after colonoscopy and polypectomy.

          Medical News & Perspectives

          New Guideline Calls for Cervical Cancer Screening to Begin at Age 25 Years

          Abstract Full Text
          free access
          JAMA. Published online November 6, 2020. doi:10.1001/jama.2020.21706

          This Medical News article discusses updates in the American Cancer Society’s cervical cancer screening guideline.

          First It Was Masks; Now Some Refuse Testing for SARS-CoV-2

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 6, 2020. doi:10.1001/jama.2020.22003

          This Medical News feature examines the problem of people refusing to be tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

          November 2, 2020
          Viewpoint

          Science Denial and COVID Conspiracy Theories: Potential Neurological Mechanisms and Possible Responses

          Abstract Full Text
          free access has active quiz
          JAMA. Published online November 2, 2020. doi:10.1001/jama.2020.21332

          This Viewpoint discusses possible parallels between the distortion in sensory information and faulty monitoring of ideas characteristic of some patients with neurodegenerative diseases (dementia with Lewy bodies and Capgras syndrome, frontotemporal dementia) and the creation and maintenance of false conspiratorial beliefs about the COVID-19 pandemic in healthy populations that has hobbled an effective national response in the US.

          JAMA Insights

          Clinical Update

          Preparing for the 2020-2021 Influenza Season

          Abstract Full Text
          has audio
          JAMA. Published online November 2, 2020. doi:10.1001/jama.2020.21849

          This JAMA Insights Clinical Update discusses the importance of established influenza prevention and control measures, including influenza vaccination and antiviral treatment, as the Global North enters its first influenza season in the COVID-19 pandemic.

          JAMA Patient Page

          High-risk Groups for Influenza Complications

          Abstract Full Text
          free access has audio
          JAMA. Published online November 2, 2020. doi:10.1001/jama.2020.21869

          This JAMA Patient Page describes the groups of people who are at high risk of complications from influenza infection, how to reduce risk through vaccination, and steps high-risk people should take if they develop influenza symptoms.

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