This unblinded cluster randomized trial compares the effects of an emergency department (ED)–based comprehensive, guideline-recommended care bundle vs usual care on the number of days alive and out of the hospital at 30 days in older patients with acute heart failure cared for at French hospitals.
This study compares pathogenic variant detection accuracy in cancer-disposition genes of prostate cancer and melanoma cohort biopsy samples using deep learning vs standard genetic analysis methods.
This study examines the association of blood lead levels in childhood with MRI measures of brain integrity as well as cognitive function assessments at age 45 years in a New Zealand birth cohort.
This study describes financial penalties levied on pharmaceutical companies for illegal activities by type of activity and dollar value between 2003 and 2016.
In this Viewpoint, Anthony Fauci and colleagues at NIAID emphasize the continued importance of low-tech public health practices, such as wearing masks, limiting large gatherings, hand washing, and physical distancing, to help control the COVID-19 pandemic even after safe and effective vaccines become available until distribution and uptake of vaccines confer herd immunity on a population level.
This Viewpoint reviews systems in place to monitor postlicensure vaccine safety, and recommends harmonizing end points and protocols across vaccine trials and surveillance systems to enable timely identification and reliable evaluation of potential adverse events.
This Viewpoint explains the “test-negative” modified case-control design commonly used for evaluating vaccine effectiveness, describes why it may be lead to biased estimates of COVID-19 vaccine effectiveness in patients with severe illness more likely to test negative, and proposes potential approaches to correcting the bias, including incorporation of clinical assessment of cases.
This Viewpoint summarizes the report of the International Commission on the Clinical Use of Human Germline Genome Editing sponsored by the US National Academy of Medicine and the UK Royal Society, enumerating technical, regulatory, and ethical standards that need to be met before HHGE can be used on human embryos.
In this narrative medicine essay, an internist shares how the COVID-19 pandemic disrupted the work-life balance she had attained and how the metaphor of aortic dissection—shear forces tearing arterial layers apart, managed with blood pressure—gave her a means to imagine how to reduce the opposing forces in her life on the way toward equilibrium.
This narrative review summarizes recent advances in the diagnosis and management of bladder cancer, including updates on its epidemiology, pathophysiology, molecular biology, and developments in surgical procedures and targeted treatments.
A 70-year-old man with a 2-year history of nasal congestion, rhinorrhea, and chronic cough developed yellow discoloration and thickening of his fingernails and toenails and progressive exertional dyspnea and edema of both lower extremities. ANA was positive (1:160, nucleolar pattern), a chest radiograph was unrevealing, and sinus CT showed bilateral maxillary and posterior ethmoidal sinusitis. What is the diagnosis and what would you do next?
This story examines the potential roadblocks to vaccinating millions of long-term care workers against COVID-19, a task that is considered to be a critical step in protecting vulnerable nursing home residents.
This JAMA Patient Page summarizes treatment options for early, invasive, and advanced bladder cancer.
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