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          November 17, 2020, Vol 324, No. 19, Pages 1925-2006

          In This Issue of JAMA

          Audio Highlights

          Abstract Full Text
          free access online only has audio
          JAMA. 2020;324(19):e200045. doi:10.1001/jama.2020.0045
          Original Investigation

          Effect of an Emergency Department Care Bundle on 30-Day Hospital Discharge and Survival Among Elderly Patients With Acute Heart Failure: The ELISABETH Randomized Clinical Trial

          Abstract Full Text
          has active quiz
          JAMA. 2020;324(19):1948-1956. doi:10.1001/jama.2020.19378

          This unblinded cluster randomized trial compares the effects of an emergency department (ED)–based comprehensive, guideline-recommended care bundle vs usual care on the number of days alive and out of the hospital at 30 days in older patients with acute heart failure cared for at French hospitals.

          Detection of Pathogenic Variants With Germline Genetic Testing Using Deep Learning vs Standard Methods in Patients With Prostate Cancer and Melanoma

          Abstract Full Text
          has active quiz
          JAMA. 2020;324(19):1957-1969. doi:10.1001/jama.2020.20457

          This study compares pathogenic variant detection accuracy in cancer-disposition genes of prostate cancer and melanoma cohort biopsy samples using deep learning vs standard genetic analysis methods.

          Association of Childhood Lead Exposure With MRI Measurements of Structural Brain Integrity in Midlife

          Abstract Full Text
          JAMA. 2020;324(19):1970-1979. doi:10.1001/jama.2020.19998

          This study examines the association of blood lead levels in childhood with MRI measures of brain integrity as well as cognitive function assessments at age 45 years in a New Zealand birth cohort.

          Research Letter

          Financial Penalties Imposed on Large Pharmaceutical Firms for Illegal Activities

          Abstract Full Text
          JAMA. 2020;324(19):1995-1997. doi:10.1001/jama.2020.18740

          This study describes financial penalties levied on pharmaceutical companies for illegal activities by type of activity and dollar value between 2003 and 2016.

          Viewpoint

          Preventing the Spread of SARS-CoV-2 With Masks and Other “Low-tech” Interventions

          Abstract Full Text
          free access has active quiz has multimedia has audio
          JAMA. 2020;324(19):1935-1936. doi:10.1001/jama.2020.21946

          In this Viewpoint, Anthony Fauci and colleagues at NIAID emphasize the continued importance of low-tech public health practices, such as wearing masks, limiting large gatherings, hand washing, and physical distancing, to help control the COVID-19 pandemic even after safe and effective vaccines become available until distribution and uptake of vaccines confer herd immunity on a population level.

          Postapproval Vaccine Safety Surveillance for COVID-19 Vaccines in the US

          Abstract Full Text
          free access has active quiz
          JAMA. 2020;324(19):1937-1938. doi:10.1001/jama.2020.19692

          This Viewpoint reviews systems in place to monitor postlicensure vaccine safety, and recommends harmonizing end points and protocols across vaccine trials and surveillance systems to enable timely identification and reliable evaluation of potential adverse events.

          Postlicensure Evaluation of COVID-19 Vaccines

          Abstract Full Text
          free access has active quiz
          JAMA. 2020;324(19):1939-1940. doi:10.1001/jama.2020.19328

          This Viewpoint explains the “test-negative” modified case-control design commonly used for evaluating vaccine effectiveness, describes why it may be lead to biased estimates of COVID-19 vaccine effectiveness in patients with severe illness more likely to test negative, and proposes potential approaches to correcting the bias, including incorporation of clinical assessment of cases.

          Heritable Human Genome Editing: The International Commission Report

          Abstract Full Text
          has audio
          JAMA. 2020;324(19):1941-1942. doi:10.1001/jama.2020.19059

          This Viewpoint summarizes the report of the International Commission on the Clinical Use of Human Germline Genome Editing sponsored by the US National Academy of Medicine and the UK Royal Society, enumerating technical, regulatory, and ethical standards that need to be met before HHGE can be used on human embryos.

          A Piece of My Mind

          Shear Forces

          Abstract Full Text
          free access has active quiz
          JAMA. 2020;324(19):1943-1944. doi:10.1001/jama.2020.21746

          In this narrative medicine essay, an internist shares how the COVID-19 pandemic disrupted the work-life balance she had attained and how the metaphor of aortic dissection—shear forces tearing arterial layers apart, managed with blood pressure—gave her a means to imagine how to reduce the opposing forces in her life on the way toward equilibrium.

          Editorial

          Bioinformatics, Sequencing Accuracy, and the Credibility of Clinical Genomics

          Abstract Full Text
          JAMA. 2020;324(19):1945-1947. doi:10.1001/jama.2020.19939
          Review

          Bladder Cancer: A Review

          Abstract Full Text
          has active quiz has audio
          JAMA. 2020;324(19):1980-1991. doi:10.1001/jama.2020.17598

          This narrative review summarizes recent advances in the diagnosis and management of bladder cancer, including updates on its epidemiology, pathophysiology, molecular biology, and developments in surgical procedures and targeted treatments.

          JAMA Clinical Challenge

          Dyschromic Nails, Exertional Dyspnea, and Lower Extremity Edema

          Abstract Full Text
          has active quiz
          JAMA. 2020;324(19):1992-1993. doi:10.1001/jama.2020.14648

          A 70-year-old man with a 2-year history of nasal congestion, rhinorrhea, and chronic cough developed yellow discoloration and thickening of his fingernails and toenails and progressive exertional dyspnea and edema of both lower extremities. ANA was positive (1:160, nucleolar pattern), a chest radiograph was unrevealing, and sinus CT showed bilateral maxillary and posterior ethmoidal sinusitis. What is the diagnosis and what would you do next?

          Medical News & Perspectives

          Nursing Homes’ Next Test—Vaccinating Workers Against COVID-19

          Abstract Full Text
          free access has active quiz
          JAMA. 2020;324(19):1928-1930. doi:10.1001/jama.2020.21354

          This story examines the potential roadblocks to vaccinating millions of long-term care workers against COVID-19, a task that is considered to be a critical step in protecting vulnerable nursing home residents.

          News From the Food and Drug Administration

          Breast Implant Manufacturers Get Labeling Guidance

          Abstract Full Text
          free access
          JAMA. 2020;324(19):1934. doi:10.1001/jama.2020.22066

          FDA Expands Food Safety Collaboration With Mexico

          Abstract Full Text
          free access
          JAMA. 2020;324(19):1934. doi:10.1001/jama.2020.21458

          Warning Concerns Respirator Decontamination System

          Abstract Full Text
          free access
          JAMA. 2020;324(19):1934. doi:10.1001/jama.2020.22068
          The JAMA Forum

          To Truly Build the Affordable Care Act Into Universal Coverage, More Creativity Is Needed

          Abstract Full Text
          free access
          JAMA. 2020;324(19):1931-1932. doi:10.1001/jama.2020.21609
          Global Health

          Dried Blood Spots May Offer Route to Wider Antibody Testing

          Abstract Full Text
          free access
          JAMA. 2020;324(19):1933. doi:10.1001/jama.2020.21109

          Partnership to Make 120 Million COVID-19 Rapid Tests Available

          Abstract Full Text
          free access has active quiz
          JAMA. 2020;324(19):1933. doi:10.1001/jama.2020.22082

          Global Mental Health Services Are Collapsing as Demand Grows

          Abstract Full Text
          free access
          JAMA. 2020;324(19):1933. doi:10.1001/jama.2020.22085
          Poetry and Medicine

          Voyager

          Abstract Full Text
          free access
          JAMA. 2020;324(19):2001. doi:10.1001/jama.2020.14356
          JAMA Revisited

          State Medicine vs Fads: By Granville P. Conn, A.M., M.D., Concord, N. H.

          Abstract Full Text
          free access
          JAMA. 2020;324(19):2002. doi:10.1001/jama.2019.13708
          JAMA Patient Page

          Bladder Cancer

          Abstract Full Text
          free access has audio
          JAMA. 2020;324(19):2006. doi:10.1001/jama.2020.17601

          This JAMA Patient Page summarizes treatment options for early, invasive, and advanced bladder cancer.

          Comment & Response

          Assessing Alternative Payment Models

          Abstract Full Text
          JAMA. 2020;324(19):1997-1998. doi:10.1001/jama.2020.19006

          Assessing Alternative Payment Models—Reply

          Abstract Full Text
          JAMA. 2020;324(19):1998. doi:10.1001/jama.2020.19021

          Testing Clinical Prediction Models

          Abstract Full Text
          JAMA. 2020;324(19):1998-1999. doi:10.1001/jama.2020.19392

          Testing Clinical Prediction Models

          Abstract Full Text
          JAMA. 2020;324(19):1999-2000. doi:10.1001/jama.2020.19389

          Testing Clinical Prediction Models—Reply

          Abstract Full Text
          JAMA. 2020;324(19):2000. doi:10.1001/jama.2020.19413
          JAMA Masthead

          JAMA

          Abstract Full Text
          free access
          JAMA. 2020;324(19):1925-1926. doi:10.1001/jama.2019.13701
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