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            Diabetes and Endocrinology

            Explore the latest in diabetes and endocrinology, including advances in the diagnosis and management of diabetes, thyroid disorders, and more.

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            • Trijardy XR—A New 3-Drug Combination for Type 2 Diabetes
              JAMA
              Review
              December 15, 2020

              This Medical Letter compares a newly approved fixed-dose combination pill comprising the sodium-glucose cotransporter 2 inhibitor empagliflozin, the dipeptidyl peptidase-4 inhibitor linagliptin, and extended-release metformin, with available formulations of each of the pill’s individual components for oral treatment of type 2 diabetes in adults.

              Clinical Pharmacy and Pharmacology Diabetes
              Full Text | pdf link PDF
            • Effectiveness of Molecular Testing Techniques for Diagnosis of Indeterminate Thyroid Nodules: A Randomized Clinical Trial
              JAMA Oncology
              Research
              December 10, 2020

              This randomized clinical trial compares the diagnostic performance between an RNA test and a DNA-RNA test in patients with thyroid nodules.

              Endocrinology Otolaryngology Thyroid Disorders Endocrine Cancer Oncology
              Full Text | pdf link PDF
            • Urinary Magnesium in the Evaluation of Hypomagnesemia
              JAMA
              Case Report
              December 8, 2020

              A 63-year-old woman with type 2 diabetes was referred for refractory hypomagnesemia (1.4 mg/dL; low normal, 1.8 mg/dL). Her medications included liraglutide, metformin, lisinopril, and magnesium oxide (400 mg twice daily). A recent hemoglobin A1c level was 10.8%, and her urinary magnesium was 117 mg. How do you interpret the urine level, and what would you do next?

              Clinical Challenge Acid Base, Electrolytes, Fluids Diabetes
              Full Text | pdf link PDF | CME & MOC is active quiz
            • Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes
              JAMA Network Open
              Research
              December 4, 2020

              This cohort study examines the mechanisms, risk factors, and outcomes associated with acute kidney injury during pediatric diabetic ketoacidosis.

              Critical Care Medicine Diabetes Acid Base, Electrolytes, Fluids Pediatrics Acute Kidney Injury
              Full Text | pdf link PDF open access
            • Teprotumumab for Optic Neuropathy in Thyroid Eye Disease
              JAMA Ophthalmology
              Case Report
              December 3, 2020

              This case report describes a case of compressive optic neuropathy in thyroid eye disease that was sucessfully resolved with teprotumumab.

              Ophthalmology Orbit Thyroid Disorders Endocrinology Neuro-ophthalmology
              Full Text | pdf link PDF
            • Out-of-Pocket Costs for Novel Guideline-Directed Diabetes Therapies Under Medicare Part D
              JAMA Internal Medicine
              Research
              December 1, 2020

              This study examines cost sharing for novel second-line diabetes treatment agents under Medicare Part D.

              Clinical Pharmacy and Pharmacology Diabetes Health Care Policy Health Care Economics, Insurance, Payment Pharmacoeconomics
              Full Text | pdf link PDF
            • Evaluation and Treatment of Patients With Hypercortisolism: A Review
              JAMA Surgery
              Review
              December 1, 2020

              This narrative review assesses the evaluation and treatment of patients with hypercortisolism.

              Endocrine Surgery Endocrinology Surgery
              Full Text | pdf link PDF | CME & MOC is active quiz
            • Interaction Between the Distribution of Diabetic Retinopathy Lesions and the Association of Optical Coherence Tomography Angiography Scans With Diabetic Retinopathy Severity
              JAMA Ophthalmology
              Research
              December 1, 2020

              This cross-sectional study evaluates the association of the distribution of diabetic retinopathy lesions with optical coherence tomography angiography (OCTA) metrics and the severity of diabetic retinopathy.

              Diabetic Retinopathy Ophthalmology Retinal Disorders Ophthalmic Imaging Diabetes
              Full Text | pdf link PDF
            • Trends in Hospitalizations for Heart Failure and Ischemic Heart Disease Among US Adults With Diabetes
              JAMA Cardiology
              Research
              November 25, 2020

              This cohort study evaluates the association of heart failure and ischemic heart disease with diabetes complications.

              Cardiology Emergency Medicine Heart Failure Ischemic Heart Disease Diabetes
              Full Text | pdf link PDF
            • Clinician Be My Guide in Active Surveillance of Papillary Thyroid Microcarcinoma
              JAMA Otolaryngology–Head & Neck Surgery
              Opinion
              November 25, 2020
              Endocrinology Oncology Otolaryngology Surgery Surgical Oncology
              Full Text | pdf link PDF
            • Thyroid Cancer Active Surveillance Program Retention and Adherence in Japan
              JAMA Otolaryngology–Head & Neck Surgery
              Research
              November 25, 2020

              This cohort study examines the use of ultrasonography in an active surveillance program to suggest continued surveillance vs surgery in patients with low-risk papillary thyroid cancer.

              Head and Neck Cancer Oncology Otolaryngology Surgery Surgical Oncology
              Full Text | pdf link PDF has multimedia
            • Associations of Intensive Lifestyle Intervention in Type 2 Diabetes With Health Care Use, Spending, and Disability: An Ancillary Study of the Look AHEAD Study
              JAMA Network Open
              Research
              November 24, 2020

              This ancillary study of a randomized clinical trial examines the long-term associations of an intensive lifestyle intervention for type 2 diabetes with health care use, spending, and disability.

              Physical Activity Diabetes Diet Nutrition, Obesity, Exercise Health Care Economics, Insurance, Payment
              Full Text | pdf link PDF open access
            • Association of the Mediterranean Diet With Onset of Diabetes in the Women’s Health Study
              JAMA Network Open
              Research
              November 19, 2020

              This cohort study characterizes the relative association of conventional and novel biomarkers in Mediterranean diet–related type 2 diabetes risk reduction in a US population.

              Lifestyle Behaviors Diet Nutrition, Obesity, Exercise Cardiology Cardiovascular Risk Factors
              Full Text | pdf link PDF open access
            • Use of Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy for Primary Hyperparathyroidism: A Systematic Review and Meta-analysis
              JAMA Otolaryngology–Head & Neck Surgery
              Research
              November 19, 2020

              This meta-analysis compares surgical outcomes with and without use of intraoperative parathyroid hormone during minimally invasive parathyroidectomy.

              Endocrinology Otolaryngology Head and Neck Surgery Surgery Perioperative Care and Consultation
              Full Text | pdf link PDF
            • Assessment of Facial Morphologic Features in Patients With Congenital Adrenal Hyperplasia Using Deep Learning
              JAMA Network Open
              Research
              November 18, 2020

              This cross-sectional study evaluates the use of machine learning for prediction of congenital adrenal hyperplasia based on distinct facial morphologic features.

              Endocrinology Health Informatics
              Full Text | pdf link PDF open access
            • Effects of α-Cyclodextrin on Cholesterol Control and Hydrolyzed Ginseng Extract on Glycemic Control in People With Prediabetes: A Randomized Clinical Trial
              JAMA Network Open
              Research
              November 17, 2020

              This randomized clinical trial assesses the efficacy of α-cyclodextrin for cholesterol control and that of hydrolyzed ginseng for glycemic control in people with prediabetes and overweight or obesity.

              Diabetes Cardiovascular Risk Factors Cardiology Dyslipidemia
              Full Text | pdf link PDF open access
            • Clinical Effects of Balanced Crystalloids vs Saline in Adults With Diabetic Ketoacidosis: A Subgroup Analysis of Cluster Randomized Clinical Trials
              JAMA Network Open
              Research
              November 16, 2020

              This subgroup analysis of 2 cluster randomized clinical trials examines adults presenting to the emergency department with diabetic ketoacidosis and determines how long it takes to reach resolution by treating with balanced crystalloids vs saline.

              Critical Care Medicine Emergency Medicine Diabetes Acid Base, Electrolytes, Fluids
              Full Text | pdf link PDF open access
            • Applicability of US Food and Drug Administration Labeling for Dapagliflozin to Patients With Heart Failure With Reduced Ejection Fraction in US Clinical Practice: The Get With the Guidelines–Heart Failure (GWTG-HF) Registry
              JAMA Cardiology
              Research
              November 13, 2020

              This cohort study evaluates candidacy for initiation of dapagliflozin based on the US Food and Drug Administration label among contemporary US patients with heart failure with reduced ejection fraction and describes potential barriers to therapeutic optimizations.

              Cardiology Clinical Pharmacy and Pharmacology Heart Failure Diabetes
              Full Text | pdf link PDF
            • Trends in Poor Health Indicators Among Black and Hispanic Middle-aged and Older Adults in the United States, 1999-2018
              JAMA Network Open
              Research
              November 11, 2020

              This cross-sectional study evaluates which health indicators have improved or worsened among Black and Hispanic middle-aged and older adults since the Minority Health and Health Disparities Research and Education Act of 2000.

              Cardiology Geriatrics Cardiovascular Risk Factors Health Care Policy Health Policy
              Full Text | pdf link PDF open access
            • Use of Topical Sirolimus (Rapamycin) for Treating Confluent and Reticulated Papillomatosis
              JAMA Dermatology
              Case Report
              November 11, 2020

              This case report describes an adolescent male with a history of prediabetes and obesity who presented with a diagnosis of confluent and reticulated papillomatosis with features of acanthosis nigricans.

              Dermatology Obesity Diabetes Adolescent Medicine Pediatrics
              Full Text | pdf link PDF
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